Effect of fibrinogen like protein 1 on cisplatin-resistance in laryngeal carcinoma through targeting integrinβ1 in vivo and in vitro
FGL1 plays a pivotal role in CDDP resistance development by activating the Integrinβ1-dependent pro-survival pathway in laryngeal carcinoma. Therapeutic targeting of FGL1 may represent a promising strategy to circumvent chemoresistance and improve clinical outcomes for CDDP-resistant laryngeal cancer patients.
Authors
- Hongzhou Ge (ORCID: https://orcid.org/0000-0002-5356-3312)
- Hui Dong (ORCID: https://orcid.org/0000-0001-5526-8926)
- Zhen Li (ORCID: https://orcid.org/0000-0002-6418-9485)
- Tao Li (ORCID: https://orcid.org/0000-0002-6427-0830)
- Hang Yu (ORCID: https://orcid.org/0009-0000-8477-3358)
- Xiaoyong Wang (ORCID: https://orcid.org/0000-0002-8338-9773)
- Jianlin Fang
- Yun Liu (ORCID: https://orcid.org/0000-0002-8158-3783)
Institutions
- Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Linzi District People's Hospital (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Yantaishan Hospital (CN)
- Central Hospital of Zibo (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1007/s12672-025-03337-x
- Citations
- 1
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 1.52