EGFR-Pathway Inhibiting Anticancer Mechanisms of Pteridophytic Bioactive Compounds: A Network Pharmacology and Molecular Docking Approach

This study used network pharmacology and molecular docking to assess the anticancer potential of Polypodiaceae pteridophytes. Key bioactive compounds were discovered and assessed for pharmacokinetics, target prediction, and pathway involvement. A compound-target network identified 246 common targets with substantial interaction patterns. Enrichment analysis identified EGFR signaling as a key route. Docking demonstrated the high binding of drugs to targets such as AKT1, SRC, and EGFR. The findings show that Polypodiaceae components offer potential as anticancer drugs, which justifies additional experimental confirmation.