Formulation and Optimization of Buccal Films of Piroxicam by Using Central Composite Design

The current study is concerned with the formulation and optimization of buccal films of Piroxicam employing central composite design. Solvent casting was used to create the Piroxicam buccal films. Utilising FT-IR analysis, drug excipient compatibility tests were carried out. The concentration of polymers such as Sodium alginate and Polyvinylpyrrolidone K30 were selected as independent variables. Drug release and mucoadhesion time were selected as dependent variables. The model was found to be nonlinear. As a result, the central composite design system was recommended. Research using FT-IR showed that there isn't much of an interaction between the drug and the excipients. Mucoadhesion time of prepared formulations varied from 5 hr to 8 hr. Percentage drug release of all formulations were in the range of 90% to 99.3%. It was determined to produce Piroxicam mucoadhesive buccal films with fewer trails and greater quality characteristics using the central composite design.