Sensorimotor Cortex High Frequency Oscillations Characterize Motor Symptom Severity during <scp>Deep Brain Stimulation</scp> Surgery for Parkinson's Disease
How motor parkinsonism alters electrophysiology in cerebral cortex is unclear. Our findings suggest that both the severity of parkinsonism and its improvement from the microlesion effect are associated most closely with changes in high-frequency oscillatory activity in primary sensorimotor cortex. Better understanding the cortical dynamics of movement disorders could guide novel paradigms for adaptive DBS. ANN NEUROL 2026;99:480-491.
Authors
- Zachary T. Irwin (ORCID: https://orcid.org/0000-0002-1379-4159)
- Christopher L. Gonzalez (ORCID: https://orcid.org/0000-0001-8816-4445)
- B.L. Guthrie
- Christopher P. Hurt (ORCID: https://orcid.org/0000-0001-8861-9876)
- Arie Nakhmani (ORCID: https://orcid.org/0000-0002-0987-4834)
- Joseph W. Olson (ORCID: https://orcid.org/0000-0002-2783-1395)
- Jeevan Kumar Jadapalli (ORCID: https://orcid.org/0000-0002-0871-0758)
- Harrison C. Walker (ORCID: https://orcid.org/0000-0002-4601-3486)
- Melissa H. Wade
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1002/ana.78077
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00