Protective effects of estradiol on neuroinflammation in chronic obstructive pulmonary disease related depression
Our findings indicate that E2 protects against depression-like behavior induced by CS, which may be related to the activation of microglia and M1 polarization through the ERK1/2 and JNK pathways. Furthermore, estrogen levels appear to play a crucial role in the anti-neuroinflammatory processes associated with the onset and progression of depression in COPD.
Authors
- Wenju Lu (ORCID: https://orcid.org/0000-0002-5035-9287)
- Zheng Han (ORCID: https://orcid.org/0000-0002-2367-2454)
- Qinghui Huang
- Zili Zhang (ORCID: https://orcid.org/0000-0002-8544-2339)
- Xiaoyan Luo (ORCID: https://orcid.org/0009-0006-3859-9081)
- Yuanyuan Li (ORCID: https://orcid.org/0009-0006-4747-8564)
- Guizhen Zhang (ORCID: https://orcid.org/0000-0001-6240-3751)
- Jia Lu (ORCID: https://orcid.org/0000-0001-5084-818X)
- Jingyi Xu
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Thoracic Disease
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/jtd-2025-247
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00