SYVN1 aggravates esophageal squamous cell carcinoma development by activating NF-κB pathway to facilitate macrophage M2 polarization
Overall, this study illustrated that SYVN1 promoted the M2 polarization of TAMs to induce ESCC progression by targeting DDX5 and eEF1A2 to activate NF-κB pathway.
Authors
- Zhao Huang (ORCID: https://orcid.org/0000-0001-9994-2070)
- Kang Wang (ORCID: https://orcid.org/0000-0002-4963-2979)
- Yi Shen (ORCID: https://orcid.org/0000-0001-9555-5399)
- Nan Yang (ORCID: https://orcid.org/0009-0000-5926-3663)
- Yuan Qiu (ORCID: https://orcid.org/0000-0002-8997-4367)
- Jing Luo
Institutions
- Nanjing General Hospital of Nanjing Military Command (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Thoracic Disease
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/jtd-2025-285
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00