Integrative analysis of fatty acid metabolism and identification of ANLN as a novel prognostic marker in lung adenocarcinoma
This work delineates FA metabolic heterogeneity and its predictive function of personalized treatment in LUAD. <i>ANLN</i> is established as both a prognostic biomarker and metabolic regulator through modulation of the AKT/mTOR/HIF-1α signaling axis. Our findings provide a framework for developing metabolism-targeted treatment strategies.
Authors
- Peng Jiang (ORCID: https://orcid.org/0000-0002-4218-0092)
- Xingfa Huo (ORCID: https://orcid.org/0000-0002-7302-464X)
- Xiao‐Quan Xu (ORCID: https://orcid.org/0000-0001-5493-5256)
- Xiaochun Zhang (ORCID: https://orcid.org/0000-0003-0793-9339)
- Na Zhou (ORCID: https://orcid.org/0000-0001-9488-4713)
- Fangfang Yang (ORCID: https://orcid.org/0000-0002-9803-1096)
Institutions
- Qingdao University (CN)
- Shuozhou Central Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Journal of Thoracic Disease
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/jtd-2025-836
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00