Integrated bulk sequencing and single-cell transcriptomic profiling implicates neutrophil-driven hypoxia in atrial fibrillation development
Our integrative analysis implicates neutrophil-driven hypoxia in AF pathogenesis, while the neutrophil-based diagnostic model demonstrates robust AF and SR discrimination. However, the validity of our findings awaits confirmation through <i>in vivo</i>, <i>in vitro</i>, and external validation studies.
Authors
- Daoming Liang (ORCID: https://orcid.org/0000-0002-7733-2957)
- Huai Wang
- Huanjie Huang (ORCID: https://orcid.org/0000-0002-2198-5721)
- Jianfeng Zhang (ORCID: https://orcid.org/0000-0003-1686-9010)
- Yunpeng Guan
- Tang Zhang
- Haibo Liu (ORCID: https://orcid.org/0000-0002-4213-2883)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Journal of Thoracic Disease
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/jtd-2025-1066
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00