Self-assembled DNA nanodevices for intelligent biosensing
Leveraging sequence specificity, shape programmability, and spatial addressability, DNA nanotechnology enables the nanometer-precise construction of DNA nanodevices for a wide range of biological applications. This minireview summarizes recent progress in employing self-assembled DNA nanostructures as scaffolds for creating advanced nanodevices as biosensors. We highlight notable advancements in ultrasensitive detection, multiplexed sensing, and targeted molecular bioimaging. These self-assembled DNA nanodevices are designed for intelligent sensing of various analytes, offering innovative solutions for biomedical diagnostics and environmental surveillance. Challenges related to the detection precision, stability, and scalable production of these promising DNA-based biosensors are also discussed.
Authors
- Baoquan Ding (ORCID: https://orcid.org/0000-0003-1095-8872)
- Yongjian Chen (ORCID: https://orcid.org/0000-0002-2930-8450)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-0254-4461)
- Qiao Jiang (ORCID: https://orcid.org/0000-0003-1016-9021)
- Run Tian
Institutions
- Dalian Medical University (CN)
- National Center for Nanoscience and Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Nanoscale Horizons
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1039/d5nh00446b
- Citations
- 2
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Jilin University
- Youth Innovation Promotion Association of the Chinese Academy of Sciences
- National Key Research and Development Program of China
- Youth Innovation Promotion Association