Tacrolimus overdosing in lung transplant recipients: clinical manifestations and management

Tacrolimus overdose is common after lung transplantation. Although acute kidney injury was frequently observed, a statistically significant association could not be established in our cohort, particularly given the small sample size. CF patients appeared more vulnerable. Although severe complications are rare, they are clinically relevant. These findings underscore the importance of individualized monitoring and support a novel classification and management algorithm to guide prevention and treatment.