Lung protective ventilation alleviates intracerebral hemorrhage-induced secondary brain and lung injury in mice via the Nrf2/HO‑1 pathway
Significant lung injury was evident on the 5th day after ICH. LPV alleviated neuronal damage, improved neurobehavioral outcomes, and reduced IL-6, IL-1β, and TNF-α in lung, blood, and brain. LPV activated the Nrf2/HO-1 pathway, decreasing oxidative stress. ML385 reversed LPV's protective effects on the brain and lung.
Authors
- Qiang Guo (ORCID: https://orcid.org/0000-0002-2326-2244)
- Yibin Wang (ORCID: https://orcid.org/0000-0003-0852-0767)
- Siyu He
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Journal of Thoracic Disease
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/jtd-2025-670
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00