Biomimetic Barium Titanate/PLA Scaffold with Shape Memory and Bioelectro-Active Capacities Promotes Bone Regeneration
The BT/PLA scaffold, combining shape-memory and piezoelectric effects, shows significant bone regeneration potential. Its degradability with 4D printing may facilitate translation of personalized bone repair implants from bench to bedside. Transcriptome sequencing suggests its osteogenic effect may involve the PI3K-Akt pathway, providing a basis for optimizing molecular targets in future bone regenerative materials and reinforcing the study's scientific value in material design and mechanistic exploration.
Authors
- Huichao Fu (ORCID: https://orcid.org/0000-0002-4274-8223)
- Chunyang Xi (ORCID: https://orcid.org/0000-0002-1597-2094)
- Yongbin Jing (ORCID: https://orcid.org/0000-0002-0578-8410)
- Hui Chi
- Zhibin Geng (ORCID: https://orcid.org/0009-0009-7719-736X)
- Weifeng Hu (ORCID: https://orcid.org/0000-0001-8518-8679)
- Yang Zhang
- Xiaoyan Wang (ORCID: https://orcid.org/0000-0002-8763-289X)
- Jinglong Yan (ORCID: https://orcid.org/0000-0001-9565-3001)
- Xiaoqi Liu (ORCID: https://orcid.org/0000-0002-3317-4627)
- Wenhui Guo
- Helin Li (ORCID: https://orcid.org/0009-0004-3623-4383)
- Gongping Xu (ORCID: https://orcid.org/0000-0001-6741-0432)
- Wenbo Xu (ORCID: https://orcid.org/0009-0001-0408-4032)
- Shuai Lv (ORCID: https://orcid.org/0000-0002-9417-6861)
- Xiongjie Liang
Institutions
- Harbin Medical University (CN)
- Harbin Institute of Technology (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/ijn.s524080
- Citations
- 1
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.67