The integrin α2-osteoclast axis: a key driver of bone destruction and therapeutic target in osteosarcoma
This study uncovered that ITGA2 drives osteosarcoma progression and aggravates osteolysis via the "ITGA2-osteoclast axis", with high expression predicting poor outcomes. Mechanistically, ITGA2 promoted tumor invasion and bone metabolism imbalance by regulating osteoclastogenic signaling, while its targeted inhibition synergistically suppresses tumor growth and restores bone homeostasis, highlighting ITGA2 as a pivotal therapeutic target for osteosarcoma.
Authors
- Dongsheng Huang (ORCID: https://orcid.org/0000-0002-2824-300X)
- Huangfeng Lin
- Hongxiang Wei (ORCID: https://orcid.org/0000-0002-5637-4007)
- Kai Shi (ORCID: https://orcid.org/0000-0001-5351-1910)
- Wenming Zhang (ORCID: https://orcid.org/0000-0002-9575-7713)
- Shenglin Wang (ORCID: https://orcid.org/0000-0003-4479-9937)
- Xuanwei Chen (ORCID: https://orcid.org/0000-0003-4725-8925)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s12967-025-06906-4
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00