Cancer-associated fibroblast miR-148a-5p/CALD1/collagen VI pathway promotes proliferation in Helicobacter pylori-positive gastric cancer
Hp-stimulated CAFs played a significant role in promoting tumor proliferation in Hp + GC. Targeting its "TLR/miR-148a-5p/CALD1/collagen VI" pathway was a promising method to ease the collagen-rich microenvironment and inhibit the proliferation of GC cells. Furthermore, miR-148a-5p agomir might serve as a safer and more efficacious chemotherapeutic sensitizer for patients with Hp + GC.
Authors
- Zhixue Chen (ORCID: https://orcid.org/0000-0002-1293-7381)
- Fansheng Meng (ORCID: https://orcid.org/0000-0002-4395-8927)
- Huibin Wu (ORCID: https://orcid.org/0000-0003-1417-9294)
- He Chen (ORCID: https://orcid.org/0009-0002-4611-9974)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-1437-9918)
- Feng Zhang (ORCID: https://orcid.org/0000-0002-3214-9286)
- Xizhong Shen (ORCID: https://orcid.org/0000-0003-3748-0709)
- Wenfeng Liu (ORCID: https://orcid.org/0009-0008-4428-9324)
- Yu‐Dong Cai (ORCID: https://orcid.org/0000-0001-5664-7979)
- Si Zhang (ORCID: https://orcid.org/0000-0002-5682-4995)
- Qiuyu Jiang (ORCID: https://orcid.org/0000-0002-6888-897X)
- Ling Dong
- Ruyi Xue
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Minhang District Central Hospital (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1007/s13402-025-01116-y
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00