Gene variants of interferon induced with helicase C domain 1 in Japanese patients with Dermatomyositis-associated rapidly progressive interstitial lung disease: a genetic association study using whole-exome and Sanger sequencing
This study identified genetic biomarkers associated with the risk of RP-ILD in patients with DM. These findings suggest that analysis of IFIH1 variants may serve as a valuable tool for predicting the development of RP-ILD in this patient population.
Authors
- Hironao Hozumi (ORCID: https://orcid.org/0000-0001-5439-1543)
- Akira Yoshida (ORCID: https://orcid.org/0000-0003-3590-1637)
- Yoshiaki Zaizen (ORCID: https://orcid.org/0000-0003-2274-4599)
- Noriho Sakamoto (ORCID: https://orcid.org/0000-0002-7577-476X)
- Yasuhiko Yamano (ORCID: https://orcid.org/0000-0002-7779-9215)
- Tomoaki Hoshino (ORCID: https://orcid.org/0000-0002-0459-4913)
- Toshimasa Shimizu (ORCID: https://orcid.org/0000-0003-0036-2039)
- Yasuhiro KONDOH
- Motoko Ishida
- Hiroshi Mukae (ORCID: https://orcid.org/0000-0002-1429-5706)
- Atsushi Kawakami
- Tomoya Miyamura
- Masaki Okamoto (ORCID: https://orcid.org/0000-0002-9298-3504)
- Shinjiro Kaieda (ORCID: https://orcid.org/0009-0001-9608-1970)
- Masataka Kuwana (ORCID: https://orcid.org/0000-0003-1249-985X)
- Ken Yamamoto (ORCID: https://orcid.org/0000-0002-1531-9685)
- Takahisa Gono (ORCID: https://orcid.org/0000-0003-2964-6377)
- Takafumi Suda (ORCID: https://orcid.org/0000-0001-5300-0504)
- Norikazu Matsuo
Institutions
- Kurume University (JP)
- Aichi Medical University (JP)
- National Kyushu Medical Center (JP)
- Hamamatsu University School of Medicine (JP)
- Kurume University Medical Center (JP)
- Frederick National Laboratory for Cancer Research (US)
- Tosei General Hospital (JP)
- Nagasaki University (JP)
- Nippon Medical School (JP)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s12931-025-03379-3
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00