Combining CSF MTBR‐tau243 and plasma pTau217 ratio enhances the prediction of continuous regional tau PET burden in early Alzheimer's disease
NCT03887455 (ClarityAD) HIGHLIGHTS: Combining plasma pTau217R and CSF eMTBR‑tau243 improves tau PET prediction. The model predicts regional tau PET SUVRs with high accuracy across key regions. Single-marker models show pTau217R and eMTBR-tau243 outperform MTBR-tau243. PET‑sparing triage reduces scan burden by up to 80% at 10% false negatives. Stochastic gradient boosting enables region-specific tau PET prediction in one unified model.
Authors
- Kristin R. Wildsmith
- T. Doherty (ORCID: https://orcid.org/0000-0002-4183-5595)
- Arnaud Charil (ORCID: https://orcid.org/0000-0002-3437-1710)
- Erica Andreozzi
- Shobha Dhadda (ORCID: https://orcid.org/0000-0002-7290-7168)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Viswanath Devanarayan (ORCID: https://orcid.org/0000-0003-2059-9252)
- Kanta Horie (ORCID: https://orcid.org/0000-0001-7736-2614)
- Michael C. Irizarry (ORCID: https://orcid.org/0000-0002-0246-2511)
- Lynn D. Kramer
Institutions
- University of Illinois Chicago (US)
- Eisai (United Kingdom) (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1002/alz.70881
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Eisai