Nano-size tantalum particles suppress the osteogenic activity of osteoblasts and stimulate osteoclasts
Ta supports osseointegration and biocompatibility, but micromotion-induced nanoscale wear particles may disrupt osteoprogenitor function and enhance osteoclast activity, risking implant loosening. Thus, vigilant post-operative monitoring for nano-sized Ta particles is advisable and critical in detecting early osteolysis and ensuring implant longevity.
Authors
- Yeon Hee Lee (ORCID: https://orcid.org/0000-0003-0993-7548)
- Sang‐Soo Lee (ORCID: https://orcid.org/0000-0001-5074-7581)
- Jin‐Chul Kim (ORCID: https://orcid.org/0000-0003-3717-6096)
- Ashish Ranjan Sharma (ORCID: https://orcid.org/0000-0003-3973-6755)
- Srijan Chatterjee (ORCID: https://orcid.org/0000-0002-8282-8324)
- Jae Gyu Kim (ORCID: https://orcid.org/0000-0002-4841-9404)
- Garima Sharma (ORCID: https://orcid.org/0000-0003-1763-0730)
Institutions
- Hallym University (KR)
- Kangwon National University (KR)
- Hallym University Chuncheon Sacred Heart Hospital (KR)
Publication Details
- Journal
- Journal of Biological Engineering
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s13036-025-00571-3
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Hallym University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea