Association of hepatorenal function biomarkers with depression risk in geriatric psychiatry inpatient: a hospital-based cross-sectional study
Hepatorenal function biomarkers (ALT/AST ratio, BUN, BUN/Cr ratio) demonstrate independent associations with geriatric depression risk, suggesting potential involvement of liver-brain and kidney-brain axis in depressive pathophysiology. We recommend incorporating these biomarkers into depression risk stratification protocols for elderly inpatients and propose novel research avenues to elucidate multi-organ crosstalk mechanisms.
Authors
- Chao Yan (ORCID: https://orcid.org/0000-0001-7869-8902)
- Shijie Mao (ORCID: https://orcid.org/0000-0002-8058-1735)
- Liang Chen (ORCID: https://orcid.org/0000-0001-8016-7596)
- Fanhao Meng
- Weimin Zhou (ORCID: https://orcid.org/0000-0003-4081-1919)
- Jia-Xiang Shen
Institutions
- Huzhou Normal University (CN)
- Third People's Hospital of Huzhou (CN)
Publication Details
- Journal
- BMC Geriatrics
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s12877-025-06536-x
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- General Hospital of People’s Liberation Army