A shrinkage-based statistical method for testing group mean differences in quantitative bottom-up proteomics
The proposed statistical method offers an effective alternative to classical approaches for differential analysis of peptides in quantitative bottom-up proteomics using DIA-MS. The R software package MDstatsDIAMS is available at https://github.com/namgillee/MDstatsDIAMS .
Authors
- Juhyoung Kim
- Heejung Yang
- Namgil Lee (ORCID: https://orcid.org/0000-0003-0593-9028)
- Hojin Yoo (ORCID: https://orcid.org/0000-0002-4291-0745)
Institutions
- Gangwon Provincial University (KR)
- Kangwon National University (KR)
Publication Details
- Journal
- BMC Bioinformatics
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s12859-025-06275-1
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Kangwon National University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea