The CBS/H2S axis regulates intestinal stem cell homeostasis and radiation-induced intestinal damage
Our findings suggest that the CBS/H2S axis contributes to the regulation of ISC homeostasis and represents a potential target for radiation protection, mediated through the intervention of non-epithelial cells.
Authors
- Zhiyuan Zheng (ORCID: https://orcid.org/0000-0003-0220-5360)
- Kenan Guo
- Meijiao Gao
- Yinglian Chen (ORCID: https://orcid.org/0000-0001-9697-5088)
- Tianyu Wu (ORCID: https://orcid.org/0000-0002-4295-7172)
- Ning Zhang (ORCID: https://orcid.org/0000-0003-0768-6554)
- Yong Wang (ORCID: https://orcid.org/0000-0003-1335-8629)
- Jianming He (ORCID: https://orcid.org/0000-0003-1163-8336)
- Chen Dong (ORCID: https://orcid.org/0000-0001-5175-1662)
- Fengchao Wang (ORCID: https://orcid.org/0000-0003-0766-2173)
- Jiong Ren
- Zhifan Yang
- Wensheng Chen (ORCID: https://orcid.org/0000-0002-2853-8422)
- Xi Liang (ORCID: https://orcid.org/0009-0009-5376-1456)
- Yongping Su
Institutions
- Army Medical University (CN)
- Hebei University of Chinese Medicine (CN)
- China Datang Corporation (China) (CN)
- Southwest Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s13287-025-04704-9
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China