MicroRNA strand ratio disarray promotes temozolomide resistance in glioblastoma
Our study demonstrates that TUT4-mediated elevation of the miR-92b-3p/-5p ratio promotes COL7A1 transcription via silencing HDAC9 and alleviation of FOXP3 targeting, leading to collagen deposition and heightened TMZ resistance. Our results suggest that targeting miR-92b strand selection may serve as a potential therapeutic strategy for sensitizing GBM to TMZ.
Authors
- Zelian Li
- Zhuolun Li (ORCID: https://orcid.org/0000-0003-4164-8551)
- Ying Nan (ORCID: https://orcid.org/0000-0003-4199-7639)
- Pengfei Wu (ORCID: https://orcid.org/0000-0001-7621-5970)
- Ying Ye (ORCID: https://orcid.org/0000-0002-2683-3321)
- Jinpeng Wang (ORCID: https://orcid.org/0000-0001-5833-145X)
- Xuedong Li (ORCID: https://orcid.org/0000-0002-1872-4213)
- Yuanfei Wang (ORCID: https://orcid.org/0000-0003-4134-307X)
- Fangfang Shen (ORCID: https://orcid.org/0000-0001-7955-3633)
- Qinglin Yang (ORCID: https://orcid.org/0000-0002-6024-2517)
- Minglong Yang (ORCID: https://orcid.org/0000-0001-5725-8481)
Institutions
- University of Science and Technology of China (CN)
- Anhui University (CN)
- Harbin Medical University (CN)
- Anhui Medical University (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Anhui Provincial Center for Disease Control and Prevention (CN)
- Anhui Provincial Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s11658-025-00806-7
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00