46,XX Testicular/Ovotesticular Disorders of Sexual Development: A Single-Center Retrospective Experience
Our findings underscore the clinical and biochemical variability in 46,XX T/OT DSD. Expert evaluation and accurate diagnostic work-up are essential prior to sex assignment and to prevent misdiagnosis and inappropriate treatments. Mini-puberty was characterized by a masculinized pattern of gonadotropin secretion. The potential for functional male pubertal development should be taken into account when making sex assignment decisions. .
Authors
- María Celeste Mattone
- Santiago Weller (ORCID: https://orcid.org/0000-0003-4975-2791)
- Juan Manuel Lazzati
- Laura Galluzzo (ORCID: https://orcid.org/0000-0001-8609-6856)
- Marta Ciaccio (ORCID: https://orcid.org/0000-0002-8167-0713)
- Gabriela Guercio (ORCID: https://orcid.org/0000-0003-3122-6734)
- Mariana Costanzo (ORCID: https://orcid.org/0000-0003-0301-032X)
- Vanina Nielsen
- Esperanza Berensztein (ORCID: https://orcid.org/0000-0002-1997-6180)
- Roxana Marino (ORCID: https://orcid.org/0000-0003-4737-3042)
- María Sol Touzón (ORCID: https://orcid.org/0000-0003-0207-9552)
- Valeria Bulgach
- Marcela Bailez
- Mónica Martínez‐Gallo
- Pablo Ramírez (ORCID: https://orcid.org/0000-0002-9193-7119)
- Natalia Pérez Garrido (ORCID: https://orcid.org/0000-0002-6020-2056)
- Alicia Belgorosky (ORCID: https://orcid.org/0000-0002-4234-400X)
- Cecilia Zunana
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Garrahan Hospital (AR)
Publication Details
- Journal
- Sexual Development
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1159/000549171
- Primary Topic
- Sexual Differentiation and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00