Spatial-reprogramming derived GPNMB+ macrophages interact with COL6A3+ fibroblasts to enhance vascular fibrosis in glioblastoma
Our findings highlight the critical role of COL6A3<sup>+</sup> TAFs in regulating MDM function and spatial distribution, as well as their contribution to fibrotic tumor vasculature formation. Additionally, we propose targeting COL6A3<sup>+</sup> TAFs with cilengitide as a potential therapeutic strategy.
Authors
- Xiaoling She
- Xinmiao Long (ORCID: https://orcid.org/0000-0003-2898-0947)
- Minghua Wu (ORCID: https://orcid.org/0000-0001-5547-907X)
- Kun Deng
- Wei Gao (ORCID: https://orcid.org/0000-0003-1026-3878)
- Fan Guan
- Xuetong Li (ORCID: https://orcid.org/0000-0003-0029-2296)
- Shuai Chen (ORCID: https://orcid.org/0000-0002-8293-7491)
- Meng Huang (ORCID: https://orcid.org/0000-0002-5661-5413)
- Shi‐Yi Wang (ORCID: https://orcid.org/0000-0002-3294-5784)
- Yinfei Du (ORCID: https://orcid.org/0000-0003-4567-655X)
- Xiang Lin
Institutions
- Central South University (CN)
- Hunan University (CN)
- Ministry of Education (SA)
- Hunan Cancer Hospital (CN)
- Ministry of Education (ET)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s13073-025-01553-2
- Citations
- 6
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.75