Hypoxia-driven metastatic progression in synovial sarcoma: insights from SYO-1 and SW982 models
Our findings demonstrate that hypoxia promotes SS metastasis through activation of HIF-1α and related pathways. Fusion-positive SS cells appear particularly responsive to hypoxic cues, suggesting that targeting hypoxia-induced signaling could be a promising strategy to inhibit metastasis in SS. These results provide mechanistic insight into SS progression and support the integration of hypoxia-targeted therapies into future treatment strategies.
Authors
- Felix Reinkemeier (ORCID: https://orcid.org/0000-0003-2265-725X)
- Sonja Verena Schmidt (ORCID: https://orcid.org/0009-0000-3841-9067)
- Alexander Fiedler
- Tom Alexander Huyghebaert (ORCID: https://orcid.org/0000-0002-5556-145X)
- Julie Christoffel
- Flemming Puscz (ORCID: https://orcid.org/0000-0002-3599-9243)
- Kamran Harati (ORCID: https://orcid.org/0000-0002-0854-2782)
- Yonca Steubing
- Christoph Wallner (ORCID: https://orcid.org/0000-0002-4707-5056)
- Jannik Hinzmann
- Marius Drysch
- Maria Fueth (ORCID: https://orcid.org/0009-0009-4977-2398)
- M. Lehnhardt
Institutions
- Witten/Herdecke University (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s12885-025-15125-5
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00