Ultra-broad hybrid capture-based targeted next-generation sequencing for sensitive plasma pathogen cfDNA detection in bloodstream infections
Ultra-broad hybrid capture-based tNGS exhibits sensitivity and accuracy comparable to mNGS, effectively covering a relatively wide range of pathogens, and may serve as an economic screening tool for BSI in the future.
Authors
- Shengyang Zhang
- Ke Xu (ORCID: https://orcid.org/0000-0002-6472-7052)
- Muyun Wei (ORCID: https://orcid.org/0000-0002-5179-7676)
- Xiangzhao Ai (ORCID: https://orcid.org/0000-0002-7205-3748)
- Dejian Gu
- Min Li (ORCID: https://orcid.org/0000-0003-4386-3992)
- Shaowei Mao
- Shuangshuang Li (ORCID: https://orcid.org/0000-0003-2702-1293)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Annoroad Gene Technology (China) (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s12967-025-07258-9
- Primary Topic
- Bacterial Identification and Susceptibility Testing
- Type
- article
- Field-Weighted Citation Impact
- 0.00