Locus coeruleus degeneration is associated with orthostatic hypotension in Parkinson’s disease and multiple system atrophy
Similar levels of LC neurodegeneration were observed in PD(+)OH and MSA(±)OH. Therefore, LC measurement may be useful to differentiate PD(-)OH from MSA. Lower LC volumes additionally correlated with greater drops in MAP in both PD(+)OH and MSA(+)OH, suggesting that LC neurodegeneration may contribute to OH in both conditions.
Authors
- Paul A. Beach (ORCID: https://orcid.org/0000-0002-3657-7106)
- Daniel E. Huddleston (ORCID: https://orcid.org/0000-0003-0503-3736)
- Xiangchuan Chen (ORCID: https://orcid.org/0000-0001-9125-9920)
- Sierra Hyland
Institutions
- National Institutes of Health (US)
- Emory University (US)
- Woodruff Health Sciences Center (US)
- National Eye Institute (US)
Publication Details
- Journal
- Clinical Autonomic Research
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1007/s10286-025-01164-2
- Primary Topic
- Cardiovascular Syncope and Autonomic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Michael J. Fox Foundation for Parkinson's Research
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke