Gemigliptin Alleviates Succinate Induced Endoplasmic Reticulum Stress and Activation of Hepatic Stellate Cells
This study showed the involvement of ER stress in the activation of succinate-induced LX-2 HSCs and gemigliptin significantly reduced ER stress in HSC activation. Therefore, gemigliptin may become an anti-fibrotic agent and targeting to succinate and ER stress may be a promising therapeutic in the management of liver fibrosis.
Authors
- Giang Nguyen (ORCID: https://orcid.org/0000-0001-9269-262X)
- Eun-Hee Cho (ORCID: https://orcid.org/0000-0002-1349-8894)
- Dinh Vinh (ORCID: https://orcid.org/0000-0002-2280-1031)
- So Young Park (ORCID: https://orcid.org/0000-0003-1518-2516)
Institutions
- Kangwon National University (KR)
Publication Details
- Journal
- Journal of Korean Medical Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3346/jkms.2025.40.e304
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00