Real world implementation of AlcoChange, a smartphone digital therapeutic to improve outcomes from alcohol-related liver disease: protocol for an individually randomised parallel group controlled trial
This trial will evaluate the real-world efficacy and cost-effectiveness of AlcoChange in reducing alcohol consumption and alcohol-related harm in individuals with ARLD. The study addresses the urgent need for scalable interventions to combat the rising burden of ARLD in the UK. The pragmatic design and mixed methods approach to implementation aim to enhance the generalizability and impact of the findings. The trial will provide valuable evidence to inform clinical practice and policy regarding the use of digital therapeutics for alcohol use disorder and liver disease.
Authors
- Zia Sadique (ORCID: https://orcid.org/0000-0001-5814-0258)
- Jonathan Riddell Bamber (ORCID: https://orcid.org/0000-0002-8763-6495)
- Sean Ewings (ORCID: https://orcid.org/0000-0001-7214-4917)
- Lorraine McDonagh (ORCID: https://orcid.org/0000-0002-5122-0156)
- Linda C. Sobell (ORCID: https://orcid.org/0000-0001-7705-3993)
- Elizabeth Dixon (ORCID: https://orcid.org/0000-0002-9876-9533)
- Neil Rajoriya (ORCID: https://orcid.org/0000-0003-3892-2206)
- Gautam Mehta (ORCID: https://orcid.org/0000-0002-5696-359X)
- Fay Chinnery (ORCID: https://orcid.org/0000-0002-8082-9016)
- Mark B. Sobell (ORCID: https://orcid.org/0000-0001-6678-5742)
- Haqeeqat Gurm (ORCID: https://orcid.org/0000-0002-9213-8175)
- Andrew Cook
- Megan Lawrence (ORCID: https://orcid.org/0000-0003-4776-0616)
- Ravan Boddu
- Francesca Saffioti (ORCID: https://orcid.org/0000-0001-7635-9931)
- Beth Stuart (ORCID: https://orcid.org/0000-0001-5432-7437)
- Ravi Kumar (ORCID: https://orcid.org/0000-0002-2514-257X)
- Richard Allen
- Rajiv Jalan
- Fran Webley
Institutions
- University Hospitals Birmingham NHS Foundation Trust (GB)
- Japan Patent Office (JP)
- Nova Southeastern University (US)
- John Radcliffe Hospital (GB)
- National Institute for Health and Care Research (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Institut de Recherche en Santé Digestive (FR)
- NIHR Evaluation Trials and Studies Coordinating Centre (GB)
- University of Southampton (GB)
- University College London (GB)
Publication Details
- Journal
- Trials
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s13063-025-09005-3
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Invention for Innovation