Metabolic phenotypes and pulmonary function in aging: the mediating roles of cognitive function and depression in CHARLS
Metabolic phenotypes significantly may influence pulmonary function in aging populations, partially mediated by cognitive and mental health, with distinct sex- and age-specific patterns. However, higher PEF in overweight/obese groups warrants caution, potentially reflecting mechanical effects rather than overall respiratory benefit. Integrated metabolic and neuropsychological health management may improve respiratory outcomes in older adults.
Authors
- Wen Wu (ORCID: https://orcid.org/0000-0002-5576-2999)
- Zhenan Deng (ORCID: https://orcid.org/0000-0002-8603-728X)
- Guiyuan Cai
- Licong Su (ORCID: https://orcid.org/0000-0002-3085-909X)
- Yu Shi
- Zihao Wang (ORCID: https://orcid.org/0009-0001-9695-134X)
- Xuefei Zhang (ORCID: https://orcid.org/0000-0001-7096-9667)
- Shengli An (ORCID: https://orcid.org/0000-0002-2811-7759)
- Zhendong Liang
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Nanfang Hospital (CN)
- Zhujiang Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Public Health
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s12889-025-24927-y
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Southern Medical University
- Guangzhou Municipal Science and Technology Bureau
- Basic and Applied Basic Research Foundation of Guangdong Province