Antibiotic-driven and microbiota-targeted therapy for advanced management of pulmonary hypertension
Antibiotic-driven microbiota modulation may alleviate PH progression by targeting dysbiosis and reducing inflammation. These findings support further investigation into optimized antibiotic regimens as a therapeutic strategy for PH, particularly in hypoxic lung disease-associated cases.
Authors
- Wenju Lu (ORCID: https://orcid.org/0000-0002-5035-9287)
- Chenting Zhang (ORCID: https://orcid.org/0000-0002-7259-8895)
- Xiaosong Ben
- Yue Xing (ORCID: https://orcid.org/0000-0002-2243-9693)
- Kai Yang (ORCID: https://orcid.org/0000-0003-3044-2240)
- Jason X.‐J. Yuan (ORCID: https://orcid.org/0000-0002-0685-4862)
- Wei-feng Zhan
- Ziying Lin (ORCID: https://orcid.org/0000-0002-9388-679X)
- Jian Wang (ORCID: https://orcid.org/0000-0002-1278-256X)
- Ting Wang (ORCID: https://orcid.org/0000-0001-5512-8026)
- Chunli Liu (ORCID: https://orcid.org/0000-0001-8682-6775)
- Jiang Qian (ORCID: https://orcid.org/0000-0002-0476-3596)
- Biao Hu (ORCID: https://orcid.org/0000-0002-6458-3327)
- Han Yan (ORCID: https://orcid.org/0000-0003-2307-3918)
- Jiyuan Chen (ORCID: https://orcid.org/0000-0002-8516-720X)
- Dansha Zhou (ORCID: https://orcid.org/0000-0003-1845-8282)
- Aofeng Liu
Institutions
- Scripps Research Institute (US)
- Guangzhou Experimental Station (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Nanfang Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Southern Medical University (CN)
- Chongqing Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1186/s12931-025-03362-y
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Medical University
- State Key Laboratory of Respiratory Disease
- National Natural Science Foundation of China
- Guangdong Provincial Pearl River Talents Program
- Guangzhou Municipal Science and Technology Project