How to define low muscle mass: A critical exploration of current definitions supports a reference equation-based approach
In contrast to ALST/height<sup>2</sup>, ALST/BMI and ALST/weight were not mathematically valid. Normalization of muscle mass by these ratios cannot correctly account for the complex association of muscle mass with fat mass, BMI and age and therefore potentially confounds results when cut-offs are applied. Reference equations that adjust for age and BMI and yield standard deviation scores may offer a more valid and clinically meaningful alternative.
Authors
- Bernhard Iglseder (ORCID: https://orcid.org/0000-0002-6132-8670)
- J. Oswald (ORCID: https://orcid.org/0000-0003-3332-2121)
- Bernhard Wernly (ORCID: https://orcid.org/0000-0003-4024-0220)
- J.L. Eberhardt
- Raphael Reiter (ORCID: https://orcid.org/0000-0002-7829-5836)
- Dagmar Schaffler‐Schaden (ORCID: https://orcid.org/0000-0002-9311-7413)
- J Gomahr
Institutions
- Paracelsus Medical University (AT)
- Christian Doppler Klinik (AT)
Publication Details
- Journal
- Clinical Nutrition
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1016/j.clnu.2025.10.016
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00