Tracking lipid droplet polarity changes during PDT process with an integrated imaging and therapy probe

A triple-functional fluorescent probe (CBFO-LZ) was developed with integrated capabilities for lipid droplet (LD) targeting, polarity monitoring, and ROS generation. It reveals a novel biphasic LD polarity shift-an initial increase followed by a decrease-during self-driven PDT, providing new insight into LD behavior under oxidative stress and advancing precision PDT strategies.

Authors

Lizhou Yue (ORCID: https://orcid.org/0009-0007-1534-2256)
Xiaojun Peng (ORCID: https://orcid.org/0000-0002-8806-322X)
Mingle Li (ORCID: https://orcid.org/0000-0002-0384-9128)
Xiaoqiang Chen (ORCID: https://orcid.org/0000-0002-3379-9870)
Zehua Chen (ORCID: https://orcid.org/0000-0003-2127-7829)

Institutions

Shenzhen University (CN)
Hainan University (CN)
Qinghai Institute for Endemic Diease Prevention and Control (CN)
Hainan Medical University (CN)

Publication Details

Journal: Chemical Communications
Published: 2025-01-01
DOI: https://doi.org/10.1039/d5cc05117g
Primary Topic: Lipid metabolism and biosynthesis
Type: article
Field-Weighted Citation Impact: 0.00

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article

Tracking lipid droplet polarity changes during PDT process with an integrated imaging and therapy probe

Lizhou Yue, Xiaojun Peng, Mingle Li, Xiaoqiang Chen et al.

Jan 1, 2025

Chemical Communications

Lipid metabolism and biosynthesis

article

Tracking lipid droplet polarity changes during PDT process with an integrated imaging and therapy probe

Lizhou Yue, Xiaojun Peng, Mingle Li, Xiaoqiang Chen, Zehua Chen

January 1, 2025article en

Abstract

A triple-functional fluorescent probe (CBFO-LZ) was developed with integrated capabilities for lipid droplet (LD) targeting, polarity monitoring, and ROS generation. It reveals a novel biphasic LD polarity shift-an initial increase followed by a decrease-during self-driven PDT, providing new insight into LD behavior under oxidative stress and advancing precision PDT strategies.

Chemical CommunicationsVol. 61(96)

Shenzhen University (CN), Hainan University (CN), Qinghai Institute for Endemic Diease Prevention and Control (CN), Hainan Medical University (CN)

Openalex Percentile: Top 69%

Lipid metabolism and biosynthesis

DOI Source OpenAlex

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Tracking lipid droplet polarity changes during PDT process with an integrated imaging and therapy probe — Lizhou Yue, Xiaojun Peng, et al. · Chemical Communications (2025) | TGRS Research Map | TGRS