CD8+ CD103+ regulatory T cells attenuate desiccating stress-induced dry eye disease by suppressing CD4+ T cell-mediated inflammation and preserving ocular surface integrity in mice
CD8<sup>+</sup>CD103<sup>+</sup> T cells exert immunomodulatory and tissue-protective effects in DS-induced DED by suppressing pathogenic CD4<sup>+</sup> T cell responses and restoring a favorable cytokine balance. These findings highlight their potential therapeutic role in ocular surface inflammation and immune-mediated dry eye disease.
Authors
- Qian Zhu (ORCID: https://orcid.org/0000-0002-1203-3278)
Institutions
- Qingdao University (CN)
Publication Details
- Journal
- American Journal of Translational Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.62347/qbnn6883
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Saud University