Discovering Potential Drug Targets for Irritable Bowel Syndrome Through Genetic Insights: A Mendelian Randomization and Colocalization Study
This study proposes two potential therapeutic targets for IBS: P2RY14 and ATRAID. Drugs aimed at targeting these two genes have a greater chance of success in clinical trials, potentially facilitating the prioritization of IBS drug development and lowering associated costs.
Authors
- Yitong Li (ORCID: https://orcid.org/0009-0002-6116-0609)
- Yali Yuan
- Muyuan Wang (ORCID: https://orcid.org/0009-0009-2226-6313)
- Jiao Yao (ORCID: https://orcid.org/0000-0002-0131-4015)
- Yanqiu Yu (ORCID: https://orcid.org/0000-0002-7953-6320)
- Xinyu Lu (ORCID: https://orcid.org/0000-0002-0034-4191)
- Tangyou Mao (ORCID: https://orcid.org/0000-0003-3171-931X)
- Jiayan Hu (ORCID: https://orcid.org/0000-0001-6525-6371)
- Chune Xie (ORCID: https://orcid.org/0000-0003-4094-6485)
- Junxiang Li (ORCID: https://orcid.org/0000-0003-1819-8185)
- Wenji Zhang (ORCID: https://orcid.org/0000-0003-1500-6627)
- Zhengdao Lin (ORCID: https://orcid.org/0009-0001-0309-6357)
- Yingdi Qu
- Chengtao Liang
Institutions
- Beijing University of Chinese Medicine (CN)
- Shenzhen Bao'an District People's Hospital (CN)
Publication Details
- Journal
- Gastroenterology Research and Practice
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/grp/7800569
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shenzhen Science and Technology Innovation Program