Gene and metabolite changes triggered by downregulation of JUNB and ZNF281 in idiopathic pulmonary arterial hypertension: potential mechanisms revealed by multi-omics study
The study underscores the intimate connection between transcription factor (e.g., JUNB, ZNF281)-regulated gene expression (e.g., <i>LDHB</i>, <i>IRS2</i>) and metabolite (e.g., glucose, L-glutamine) alterations in PAH, revealing that key genes and metabolites closely tied to the disease's pathology.
Authors
- Yanfang Zong
- Tingting Xiao (ORCID: https://orcid.org/0000-0001-7311-4496)
- Xunwei Jiang
- J. Y. Tian (ORCID: https://orcid.org/0009-0007-7622-4632)
- Cuilan Hou (ORCID: https://orcid.org/0000-0003-3972-1625)
- Sirui Song
- Wei Liu (ORCID: https://orcid.org/0009-0001-6324-3830)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Translational Pediatrics
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tp-2025-370
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00