Immune cell reconstitution after allogeneic hematopoietic stem cell transplantation in children with β-thalassemia major
(I) Post-transplant CMV infection, CD34<sup>+</sup> cell content in the graft, and donor type were independent influences on the level of T- and B-cell reconstitution after transplantation in children with TM. (II) No anemic heart disease before transplantation, donor-recipient blood type compatibility, no aGVHD after transplantation, no cGVHD after transplantation, and HLA 10/10 compatible transplantation are favorable for immune cell reconstitution after transplantation. (III) CMV infection and EBV infection after transplantation favored T-cell reconstitution, while CMV infection was detrimental to B-cell reconstitution.
Authors
- Lanzhou Jia
- Xianmin Guan (ORCID: https://orcid.org/0009-0003-2282-8730)
- Ya Zhou (ORCID: https://orcid.org/0000-0001-6168-4088)
- Ying Dou (ORCID: https://orcid.org/0000-0001-9037-6420)
- Jie Yu (ORCID: https://orcid.org/0000-0002-5309-6662)
- Xiaoying Lei
- Luying Zhang (ORCID: https://orcid.org/0000-0002-0796-9522)
- Yan Meng
Institutions
- Children's Hospital of Chongqing Medical University (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Translational Pediatrics
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tp-2025-325
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00