Neuroprotective effects of caffeine, erythropoietin, magnesium sulfate, and thyroxine in preterm infants: a network meta-analysis

The neuroprotective effects of caffeine were observed in the reduction of NDI and cerebral palsy, whereas magnesium sulfate, given to pregnant women at risk of preterm birth, had a protective effect in reducing the risk of cerebral palsy. The analysis of the SUCRA value indicated that caffeine may offer greater benefits compared to other medications in the neuroprotection of premature infants. The findings of this network meta-analysis ought to be regarded as theoretical rather than validated. Additional trials are necessary to validate the existing findings.