Noninfectious endocarditis as a novel cardiac manifestation of glycogen storage disease type IV: a case report

This is the first report of non-infectious endocarditis, also known as Libman-Sacks endocarditis, in a patient with GSD IV as a primary manifestation of their underlying metabolic disorder, representing a novel cardiac manifestation of the disease. In patients with GSD IV who develop valvular lesions and have a negative infectious work-up, clinicians should consider noninfectious endocarditis as a progression of their genetic disease. Regular cardiac surveillance may be warranted in this population to identify valvular involvement early.