Mendelian Randomization Reveals Unidirectional Links Between Amyloid-β and Tau in Alzheimer’s Disease
Our findings suggest a causal relationship between Aβ burdens and tau burdens in AD, reinforcing the notion of Aβ as a pivotal upstream factor in AD pathogenesis.
Authors
- Jun Pyo Kim (ORCID: https://orcid.org/0000-0003-4376-3107)
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Sang Won Seo (ORCID: https://orcid.org/0000-0002-8747-0122)
- Kwangsik Nho (ORCID: https://orcid.org/0000-0002-7624-3872)
- Hyun-Woo Lee (ORCID: https://orcid.org/0009-0003-7212-2162)
- Han‐Na Kim (ORCID: https://orcid.org/0000-0001-7053-7469)
- Bo‐Hyun Kim (ORCID: https://orcid.org/0009-0008-7155-3506)
Institutions
- Samsung (South Korea) (KR)
- Samsung Medical Center (KR)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Dementia and Neurocognitive Disorders
- Published
- 2025-01-01
- DOI
- https://doi.org/10.12779/dnd.2025.24.4.246
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Samsung
- Korea National Institute of Health
- Institute for Information and Communications Technology Promotion