Effect of pigment epithelium-derived factor on prostaglandin E2 receptors (EP2/EP4) in glucocorticoid-induced osteoporosis in rats
These findings indicate that PEDF exerts protective effects against GIOP and may modulate bone metabolism through EP2/EP4 signalling pathways. PEDF shows promise as a potential therapeutic agent for preventing bone loss in GIOP.
Authors
- Fatih Alper (ORCID: https://orcid.org/0000-0002-9483-8861)
- Erdem Toktay (ORCID: https://orcid.org/0000-0002-0715-2707)
- Hamza Halıcı (ORCID: https://orcid.org/0000-0002-2028-6603)
- Zekai Halıcı (ORCID: https://orcid.org/0000-0001-6854-6059)
- Zerrin Kutlu (ORCID: https://orcid.org/0000-0002-6279-9810)
- Zafer Bayraktutan (ORCID: https://orcid.org/0000-0002-4324-5943)
- Ahmet Yalçın (ORCID: https://orcid.org/0000-0002-9708-0988)
- Adem Maman (ORCID: https://orcid.org/0000-0002-7742-1028)
Institutions
- Kafkas University (TR)
- Atatürk University (TR)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1093/jpp/rgaf102
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00