Chalcogenylation of 4-hydroxycoumarins and 4-hydroxyquinolinones in water at room temperature

A mild and efficient iodine-promoted method has been developed for synthesizing 3-selenyl and 3-sulfenyl derivatives of 4-hydroxycoumarins and 4-hydroxyquinolinones in aqueous media at room temperature. The practicality of this approach was further validated by control experiments that support plausible reaction pathways and by its successful application to the synthesis of 3,3'-sulfenyl-bis-4-hydroxycoumarins.

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Publication Details

Journal
Chemical Communications
Published
2025-01-01
DOI
https://doi.org/10.1039/d5cc04270d
Primary Topic
Sulfur-Based Synthesis Techniques
Type
article
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article

Chalcogenylation of 4-hydroxycoumarins and 4-hydroxyquinolinones in water at room temperature

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Chemical Communications
Sulfur-Based Synthesis Techniques
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Chalcogenylation of 4-hydroxycoumarins and 4-hydroxyquinolinones in water at room temperature

Junchao Lu, Guang-Yao Zhao, Dulin Kong, Guiwei Yao, Jiao Chen, Shusen Zheng, Haoyu Tian, Xun Chen, Xian Zhong, Xiaolin Cui, Xingjian Wang, Wenyan Wei
article en

Abstract

A mild and efficient iodine-promoted method has been developed for synthesizing 3-selenyl and 3-sulfenyl derivatives of 4-hydroxycoumarins and 4-hydroxyquinolinones in aqueous media at room temperature. The practicality of this approach was further validated by control experiments that support plausible reaction pathways and by its successful application to the synthesis of 3,3'-sulfenyl-bis-4-hydroxycoumarins.

Chemical CommunicationsVol. 61(96)
Hainan Medical University (CN)
Openalex Percentile: Top 76%
Sulfur-Based Synthesis Techniques
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