Disparities in gastrointestinal cancer trials recruitment: analyzing demographic gaps compared to the real-world
Significant demographic disparities persist in GI cancer RCTs, notably for older adults, men in certain subtypes, and racial/ethnic minority groups. These discrepancies threaten the generalizability of clinical trial evidence, potentially perpetuating gaps in care. More inclusive recruitment strategies and trial designs are essential to ensure equitable treatment outcomes for diverse patient populations.
Authors
- Elisia Maalouf
- Lynn Kobeissi
- Marita Salame (ORCID: https://orcid.org/0000-0001-5308-0145)
- Wissam Ghusn (ORCID: https://orcid.org/0000-0002-9389-6795)
- Sara F. Haddad (ORCID: https://orcid.org/0000-0002-7262-028X)
- Sandra Quezada
- Aline Charabaty (ORCID: https://orcid.org/0000-0001-9810-3662)
- Tamara Kadi
- Andrew Takchi (ORCID: https://orcid.org/0009-0002-8197-2823)
- Rudy Mrad
- Noura Jawhar (ORCID: https://orcid.org/0009-0006-1146-7222)
- Yara Salameh
Institutions
- Boston University (US)
- University of Maryland, Baltimore (US)
- Boston Children's Hospital (US)
- Albert Einstein College of Medicine (US)
- Cleveland Clinic (US)
- Mayo Clinic (US)
- Montefiore Medical Center (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- University of Pittsburgh Medical Center (US)
- Montefiore Einstein Comprehensive Cancer Center
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/jgo-2025-276
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00