A promising model for prediction of chemotherapeutic sensitivity in gastrointestinal cancers using patient-derived malignant ascites organoids
Organoids derived from malignant ascites in GI malignancies have a high culturing success rate and simulate the characteristics of <i>in vivo</i> tumors. The drug sensitivity obtained from organoids correlates well with the clinical treatment efficacy, making them an effective model for predicting chemotherapeutic sensitivity in GI cancers with peritoneal metastasis.
Authors
- Yulu Fang
- Yifan Zhao (ORCID: https://orcid.org/0000-0003-0869-5479)
- Zhong Shi (ORCID: https://orcid.org/0000-0002-0641-4875)
- Siqi Chen (ORCID: https://orcid.org/0000-0002-9498-3823)
- Jinping Xiao
- Xiaofu Yu
Institutions
- Zhejiang Chinese Medical University (CN)
- Chinese Academy of Sciences (CN)
- Wenzhou Medical University (CN)
- Zhejiang Cancer Hospital (CN)
- Hangzhou Cancer Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/jgo-2025-130
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05