Deciphering the immunometabolic axis: a mendelian randomization study of a causal cascade network from immune cell phenotypes to metabolites in esophageal cancer
This study provides genetic evidence supporting the causal roles of specific immune cell phenotypes, particularly CD38<sup>+</sup>CD20<sup>-</sup> B cells, CD33<sup>+</sup>CD14<sup>+</sup> monocytes, and CD45⁺CD33⁺HLA-DR<sup>+</sup>CD14dim myeloid cells, in promoting EC risk. Furthermore, we identified the aspartate to citrate ratio as a significant metabolic mediator in the pathway linking monocyte activity to esophageal carcinogenesis. These findings unveil a novel immunometabolic axis and highlight potential therapeutic targets for intervening in EC development.
Authors
- Dorina Gui (ORCID: https://orcid.org/0000-0002-1500-6689)
- Wenhua Liang (ORCID: https://orcid.org/0000-0002-1391-8238)
- Si‐Min Lu
- Kaichun Wu (ORCID: https://orcid.org/0000-0002-0699-9666)
- Siyu Guo (ORCID: https://orcid.org/0000-0001-6995-0352)
- Yi Feng (ORCID: https://orcid.org/0000-0001-8021-7776)
- Shubin Wang (ORCID: https://orcid.org/0000-0001-6790-6745)
- Zhengyang Yan
- Hui Sun (ORCID: https://orcid.org/0000-0002-7564-0809)
- Jingxun Wu
- Xuan Wu
- Hehui Wang
Institutions
- Guangdong Medical College (CN)
- Shenzhen University (CN)
- Shantou University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Shantou University Medical College (CN)
- Peking University Shenzhen Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/jgo-2025-774
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00