YTHDF1 regulates YTHDF2 stability via m6A-dependent mechanisms in hepatocellular carcinoma: insights from in vitro, in vivo, and multi-cohort clinical studies
YTHDF1 drives HCC progression through m6A-mediated stabilization of YTHDF2, revealing their functional synergy. Their combined spatial and expression profiles offer a superior prognostic biomarker, suggesting novel therapeutic targets.
Authors
- Zhihui H. Dai (ORCID: https://orcid.org/0000-0001-7049-7217)
- Zheng-Guang Wang (ORCID: https://orcid.org/0000-0001-8760-068X)
- Yuefan Wang (ORCID: https://orcid.org/0000-0001-5731-6143)
- Shengxian Yuan (ORCID: https://orcid.org/0000-0002-4883-0156)
- Hao-zan Yin (ORCID: https://orcid.org/0000-0002-3804-2455)
- Ming Jen Tan (ORCID: https://orcid.org/0000-0002-3583-1723)
- Zhaoguang Wang (ORCID: https://orcid.org/0000-0002-3939-2625)
- Chenyang Mu
- Zhichao Zhang (ORCID: https://orcid.org/0000-0002-2774-2384)
- Hui Liu (ORCID: https://orcid.org/0000-0001-5966-9313)
- Yang Fu (ORCID: https://orcid.org/0000-0002-8221-3354)
- Sijie Wang (ORCID: https://orcid.org/0009-0004-9098-0993)
- Jiacheng Zhang (ORCID: https://orcid.org/0000-0002-1895-5003)
- Zhi‐Xuan Li (ORCID: https://orcid.org/0000-0002-8590-875X)
- Fuchen Liu (ORCID: https://orcid.org/0000-0002-0041-7055)
- Wei Dong (ORCID: https://orcid.org/0009-0005-3616-516X)
- Xingguang Piao
- Qian-Jia Liu
Institutions
- Second Military Medical University (CN)
- Shanghai Medical Information Center (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/jgo-2025-363
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00