ZNF529 up-regulation speeds up progression and induces tyrosine kinase inhibitor resistance in hepatocellular carcinoma
Our findings suggest that ZNF529 is a promising prognostic biomarker for HCC. Its up-regulation correlates with poor prognosis, increased risk and resistance to TKI therapies. ZNF529 could serve as a potential therapeutic target, highlighting the need for further investigation into ZNF529-targeted therapies in HCC treatment.
Authors
- Yuzhen Chen (ORCID: https://orcid.org/0000-0002-3391-8841)
- Da-Tong Zeng (ORCID: https://orcid.org/0000-0002-3338-4122)
- Rong‐Quan He (ORCID: https://orcid.org/0000-0002-7752-2080)
- Kai Qin
- Diyuan Qin
- Jian‐Di Li (ORCID: https://orcid.org/0000-0001-7050-371X)
- Bin-Tong Yin
- Gang Chen (ORCID: https://orcid.org/0000-0003-2402-2987)
- Zhi‐Guang Huang (ORCID: https://orcid.org/0000-0003-4457-9491)
- Fu-Xi Li
- Lei Wang (ORCID: https://orcid.org/0000-0003-2989-5322)
- Shengsheng Zhou
- Wan-Ying Huang (ORCID: https://orcid.org/0000-0002-8314-5963)
- Gao-Peng Yao
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Yulin University (CN)
- Yulin Orthopedics Hospital of Chinese and Western Medicine (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/jgo-2025-297
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00