The SNHG3/miR-148a-3p axis-mediated high expression of DNMT1 is correlated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma
The SNHG3/miR-148a-3p/DNMT1 axis represents a novel regulatory pathway in hepatocarcinogenesis. DNMT1 overexpression could serve as a biomarker for poor prognosis, and is closely associated with enhanced immune cell infiltration and immune checkpoint expression in HCC. These findings suggest that DNMT1 may serve as a potential therapeutic target for both conventional treatment and immunotherapy in HCC patients.
Authors
- Guohui Sun (ORCID: https://orcid.org/0000-0003-2259-5431)
- Huajie Miao
- Gangrong Qu
- Ninghua Yao (ORCID: https://orcid.org/0000-0002-7607-2516)
- Jie Sun (ORCID: https://orcid.org/0000-0002-5642-0560)
- Zhao Hongyu (ORCID: https://orcid.org/0009-0003-1925-3403)
- Wenjie Zheng (ORCID: https://orcid.org/0000-0002-3073-4596)
- Yumeng Shi (ORCID: https://orcid.org/0000-0003-3949-3669)
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/jgo-2025-641
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00