Clinical Utility of Whole-Genome Sequencing to Aid Histologic Diagnosis and to Direct Personalized Medicine in Salivary Gland Cancer
WGS in SGC is achievable in clinically relevant timeframes, providing genomic information for deeper understanding of disease pathophysiology, to clarify histologic subtype and can identify actionable genomic targets which may not be found through routine sequencing technologies. Further use of WGS has the potential to improve care for patients with SGC.
Authors
- Robert Lewin Metcalf (ORCID: https://orcid.org/0000-0002-8431-1951)
- Susanne Churchill
- George J. Burghel (ORCID: https://orcid.org/0000-0001-9360-8194)
- Kevin Joseph Harrington (ORCID: https://orcid.org/0000-0002-6014-348X)
- Matt Church (ORCID: https://orcid.org/0000-0002-5825-3241)
- Guy Betts (ORCID: https://orcid.org/0000-0002-9027-2792)
- Hélene Schlecht (ORCID: https://orcid.org/0000-0002-1916-6575)
- Yatin Jain
Institutions
- Royal Marsden NHS Foundation Trust (GB)
- Institute of Cancer Research (GB)
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- The Christie NHS Foundation Trust (GB)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1200/po-25-00490
- Primary Topic
- Salivary Gland Tumors Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00