Quantifying Nuance Within Sepsis-Associated Immune Suppression Toward Diagnostic Certainty

Plain Language Summary Summary: Impact of sepsis on human T-cell function and outcome was assessed. In sepsis survivors, IFNγ-production in response to T-cell stimulation remains intact, while sepsis non-survivors display exaggerated IFNγ responses to TCR-independent stimuli. Plain Language SummaryThis study explored how sepsis affects T-cell function and patient outcomes. Researchers found that sepsis survivors maintain normal IFNγ production when their T-cells are stimulated, indicating intact immune function. However, those who did not survive sepsis showed excessive IFNγ responses to stimuli that do not involve T-cell receptor (TCR) activation, suggesting a dysregulated immune response. These findings highlight differences in immune function between sepsis survivors and non-survivors, which could inform future treatments and interventions for sepsis patients. Text is machine generated and may contain inaccuracies. FAQ

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Publication Details

Journal
Shock
Published
2025-10-21
DOI
https://doi.org/10.1097/shk.0000000000002745
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Quantifying Nuance Within Sepsis-Associated Immune Suppression Toward Diagnostic Certainty

Richard S. Hotchkiss, Robert Maile, Mahil Rao, Philip A. Efron et al.
Shock
Sepsis Diagnosis and Treatment
article

Quantifying Nuance Within Sepsis-Associated Immune Suppression Toward Diagnostic Certainty

Richard S. Hotchkiss, Robert Maile, Mahil Rao, Philip A. Efron, Patrick W. McGonagill, Charles C. Caldwell, Tyler John Loftus, Robert W. Gould, Christian B. Bergmann, Thomas S. Griffith, Lyle L. Moldawer, Kenneth E. Remy, Ricardo Ungaro, Monty B. Mazer, Vladimir P. Badovinac, Scott C. Brakenridge, Miguel Hernández-Ríos
article en

Abstract

Plain Language Summary Summary: Impact of sepsis on human T-cell function and outcome was assessed. In sepsis survivors, IFNγ-production in response to T-cell stimulation remains intact, while sepsis non-survivors display exaggerated IFNγ responses to TCR-independent stimuli. Plain Language SummaryThis study explored how sepsis affects T-cell function and patient outcomes. Researchers found that sepsis survivors maintain normal IFNγ production when their T-cells are stimulated, indicating intact immune function. However, those who did not survive sepsis showed excessive IFNγ responses to stimuli that do not involve T-cell receptor (TCR) activation, suggesting a dysregulated immune response. These findings highlight differences in immune function between sepsis survivors and non-survivors, which could inform future treatments and interventions for sepsis patients. Text is machine generated and may contain inaccuracies. FAQ

ShockVol. 65(3)
University of Iowa (US), UF Health Shands Hospital (US), Universität Ulm (DE), University of Washington (US), Washington University in St. Louis (US), Harborview Medical Center (US), University of Florida (US), Minneapolis VA Health Care System (US), University of Minnesota Medical Center (US), University School (US), University Hospital Ulm (DE), Case Western Reserve University (US), University of Cincinnati Medical Center (US), Florida College (US)
Openalex Percentile: Top 58%
Sepsis Diagnosis and Treatment
DOISourceOpenAlex
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