TGFBR2 accelerates the oxidative stress and inflammation in septic acute lung injury via METTL14-mediated m6A modification or USP7-regulated deubiquitination

TGFBR2 facilitates the inflammation and oxidative stress in sepsis-induced ALI via METTL14/IGF2BP2-mediated m6A modification or USP7-regulated deubiquitination. These findings provide a novel potential therapeutic target for the treatment of sepsis-induced ALI.

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Publication Details

Journal
Shock
Published
2025-10-21
DOI
https://doi.org/10.1097/shk.0000000000002689
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

TGFBR2 accelerates the oxidative stress and inflammation in septic acute lung injury via METTL14-mediated m6A modification or USP7-regulated deubiquitination

Xudong Lü, Zemin Xiang, Lefeng Zhang
Shock
RNA modifications and cancer
article

TGFBR2 accelerates the oxidative stress and inflammation in septic acute lung injury via METTL14-mediated m6A modification or USP7-regulated deubiquitination

Xudong Lü, Zemin Xiang, Lefeng Zhang
article en

Abstract

TGFBR2 facilitates the inflammation and oxidative stress in sepsis-induced ALI via METTL14/IGF2BP2-mediated m6A modification or USP7-regulated deubiquitination. These findings provide a novel potential therapeutic target for the treatment of sepsis-induced ALI.

Shock
Lishui City People's Hospital (CN)
Openalex Percentile: Top 72%
RNA modifications and cancer
DOISourceOpenAlex
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TGFBR2 accelerates the oxidative stress and inflammation in septic acute lung injury via METTL14-mediated m6A modification or USP7-regulated deubiquitination — Xudong Lü, Zemin Xiang, et al. · Shock (2025) | TGRS Research Map | TGRS